Dr. Mersad Alimoradi 27 Jun 2021

Ankylosing spondylitis is a progressive inflammatory disease that affects the vertebral (spine) bones.

About 300,000 Americans (nearly one percent of the adult population) have ankylosing spondylitis. It is more likely to affect men than women. It leads to back pain and stiffness that might worsen over time.

Unfortunately, there is no cure for Ankylosing Spondylitis. However, the right treatment and care can help you keep it in control and even lessen the symptoms. In some cases, treatment can also slow down the progression of the disease.

In this article, we will discuss what ankylosing spondylitis is, what symptoms you should look for, and ways to treat it.

What is AS?

Ankylosing spondylitis (AS) is a rare form of arthritis (bone inflammation). “Ankylosis" means fused bones or other hard tissue. "Spondylitis" means inflammation in your spinal bones (vertebra). It is a progressive condition that eventually fuses your vertebra together leading to back pain and stiffness.

Here is what happens in a body affected by AS:

  • The spine becomes inflamed for an unknown reason
  • As a result, the body cells deposit calcium around inflamed vertebrae
  • The excess calcium leads to new bone growth, causing your back and neck to harden up and be stiffer.

Ankylosing Spondylitis usually starts in your lower back and slowly starts affecting other body parts like your neck. Essentially, it damages your joints, causing inflammation in your vertebrae, and can leave your spine hunched. If it affects the ribs, it can also cause difficulty in breathing.

What are the Symptoms?

Signs and symptoms of ankylosing spondylitis begin in early adulthood. They mainly include pain and stiffness in your lower back and hips. These bouts of pain are more likely to occur in the morning or during periods of inactivity.

Since ankylosing spondylitis is a systemic disease, it has a wide range of symptoms that can affect nearly all body systems.

Here’s a list of all the symptoms associated with Ankylosing Spondylitis:

  • Back pain and stiffness, mostly in the morning
  • Arthritis
  • Enthesitis (inflammation tendons’ attachment sites on your bones)
  • Extreme tiredness (fatigue)
  • Poor posture or stooped shoulders
  • Loss of appetite
  • Low-grade fever
  • Weight loss
  • Fatigue
  • Anemia or low iron
  • Reduced lung function

In your joints, you might notice any of these symptoms:

  • Inflammation (redness and swelling)
  • Persistent pain
  • Stiffness
  • Soreness

What are the Risk Factors?

There are certain risk factors of AS that make you more likely to develop ankylosing spondylitis. These are:

Your sex

Men are much more prone to develop AS than women - so your sex is a risk factor.

Your age

Ankylosis usually begins in late adolescence or early adulthood.

Your Genes

Ankylosing spondylitis is linked to a certain gene called the HLA-B27 gene. If you have this gene, there is a higher chance of you getting AS. However, having this gene does not always mean that you will develop AS.

What Triggers AS Flare-Ups?

Medically, a flare-up is a sudden outburst or intensification of a condition. This usually means moderate to severe back and joint pain and stiffness.

An ankylosing spondylitis flare-up is bound to happen and can’t always be controlled. However, some people who’ve had the condition for years have identified their flare-up triggers. Understanding and getting to know your triggers can help you avoid flare-ups.

The following have been identified as triggers of AS flare-ups:


Around 80% of people with ankylosing spondylitis have reported that flare-ups are triggered by stress.

Sedentary Lifestyle

In other cases, a sedentary lifestyle can aggravate symptoms. Although it may seem like a struggle to exercise with back pain, regular physical activity can minimize your flare-ups and actually make you feel better. You do not even have to engage in a high-impact routine. Something as simple as walking and yoga can help you.

Poor Posture

Poor posture can also be a trigger for ankylosing spondylitis. Misalignment of your bones due to bad posture can lead to more frequent flare-ups. That’s why it is important to practice good posture, whether you are sitting or standing. It will not only lessen the number of flare-ups you experience but can also slow down the progression of Ankylosis.


There is a link between smoking and disease activity in people with ankylosing spondylitis. Since smoking has an inflammatory effect on the body, it is likely to cause a flare-up in people with AS.

Excessive Physical Activity

People with AS have multiple afflictions such as inflammation, stiffness, and joint pain. This means that they have limitations to what they can and cannot do. Going above and beyond these limitations can lead to a flare-up. Therefore, resting and keeping your health in check during daily activities is important.

Not Taking Medication as Directed

Although there is no cure for ankylosing spondylitis, your doctor may prescribe some to minimize the pain or slow down the progression of the disease. If you fail to take these as directed, a flare-up is more likely to happen.

Being Overweight

Since excess weight is likely to put too much pressure on joints, being overweight can also trigger flare-ups of ankylosing spondylitis.

Lack of Sleep

Sleep is the way your body repairs itself and restores its strength. For people with ankylosing spondylitis, it is important to get enough sleep since a lack of it might lead to flare-ups.

Complications of AS

In some cases, ankylosing spondylitis can progress and cause more serious complications. These can affect other body organs and not just bones and joints. Advanced complications of ankylosing spondylitis include:

Eye inflammation (uveitis)

Uveitis is one of the most common complications of ankylosing spondylitis. Eye inflammation can lead to rapid-onset eye pain, sensitivity to light, and blurred vision. In some cases, uveitis can lead to vision disturbance.

Compression Fractures

Another complication of ankylosing spondylitis is compression fractures due to severe bone thinning. The weakened vertebrae can crumble under your body’s own weight leading to a stooped posture. This is called a compression fracture, and it can sometimes lead to spinal cord injury.

Heart problems

Ankylosing spondylitis may lead to heart problems in certain cases. It can cause inflammation in your aorta, the largest artery coming out of your heart.  If this happens, the aorta can become enlarged, distorting the shape of your aortic valve at its base. Numerous heart and vascular diseases have been linked to ankylosing spondylitis. These including aortitis (inflammation of the aorta), aortic valve insufficiency, electrical disturbances, heart muscle weakness, and ischemic heart disease.

Treatment of AS

Since ankylosing spondylitis is incurable, the treatment is more aimed towards relieving the pain and stiffness from your joints. Treatment can also help prevent or delay the aforementioned complications.

It is best to start treatment when your ankylosing spondylitis is in the earlier stages. Treatment is most successful when initiated before irreversible damage to your joints ensues. This means that the sooner you get your diagnosis, the more likely it is for the treatment to be effective.

Depending on your specific case, you might benefit from any one or more of the following ankylosing spondylitis treatment methods:


Nonsteroidal anti-inflammatory drugs (NSAIDs) are usually used to treat ankylosing spondylitis. These include drugs naproxen and indomethacin. These are the most prescribed medications to control ankylosing spondylitis symptoms. In case NSAIDs don’t work, your doctor may prescribe you certain biologics such as Etanercept (Enbrel), Infliximab (Remicade), Adalimumab (Humira).

Home Remedies

The home remedies for the treatment of AS include:

  • Stay active: By keeping fit and exercising regularly, you can actually slow down the progression of your disease.
  • Apply heat and cold: Using hot bottles and ice packs on your joints can give you relief from flare-up pains.
  • Quit smoking: As you might already know, smoking is harmful. Therefore, if you make an effort to avoid smoking it can actually help you keep your condition under control.
  • Practice good posture: Sitting and sleeping in a healthy posture will not only help ease your pain but will also help you slow down the progression of ankylosing spondylitis.

We have discussed most of these in-depth in earlier sections, so have a look at that for better understanding.


Surgery is the most invasive treatment for ankylosing spondylitis. Therefore, it is only recommended if the condition progresses to such a point that daily activities are severely impaired.

There are multiple surgical procedures you can look into that will help you deal with your condition a little more effectively. These include:

  • Joint replacement surgery: If a joint is severely damaged, it might be completely replaced with a prosthesis. A joint prosthesis can be made of metal, plastic, or ceramic. It usually restores function to the affected joint and relieves pain or stiffness.
  • Osteotomy: This is when the excess bone is cut and removed. The joint is then reshaped or fused to relieve pain and stiffness.
  • Laminectomy: The most common procedure out of all of these is laminectomy. This surgery is provided to relieve pressure on nerve roots. The main thing that is done during a laminectomy is the removal of the vertebrae bone called lamina, which allows you to access the disk.

The most common procedure out of all of these is laminectomy. This surgery is provided to relieve pressure on nerve roots. The main thing that is done during a laminectomy is the removal of the vertebrae bone called lamina, which allows you to access the disk.


Surgery is the standard treatment for ankylosing spondylitis. True or False?

The treatment of ankylosing spondylitis typically involves the use of medications to reduce inflammation and stop the progression of the disease. Surgery is only an option if and when AS progresses to extreme levels.

Is there a way to prevent ankylosing spondylitis?

There are no known ways to prevent AS because it is most likely to be hereditary. It runs in families and can affect different family members to varying degrees.

What type of doctor is an expert at diagnosing and treating ankylosing spondylitis?

A rheumatologist diagnoses and treats AS. They are specially trained to diagnose and treat arthritis and related conditions of the musculoskeletal system. However, since AS leads to other complications, you may have to see other doctors such as an ophthalmologist, gastroenterologist, cardiologist, and physical therapist.

Are there any dietary changes a person with AS needs to make?

In general, having a healthy diet and lifestyle helps. However, neither fat-free, gluten-free, nor vegetarian diets have been shown to be helpful for people with ankylosing spondylitis.

Is ankylosing spondylitis serious?

Ankylosing is a serious and complex autoimmune disorder that can cause serious complications if left unchecked.

Can you live a long life with ankylosing spondylitis?

Yes, you can live a long life with ankylosing spondylitis. Despite the chronic nature of the illness, only a few people are likely to become seriously disabled and most would lead a normal life.

Does ankylosing spondylitis get worse with age?

Yes, it is a progressive disease and tends to worsen with age. However, it can also stop progressing if you follow a strict treatment regimen.

Does ankylosing spondylitis shorten life span?

About one-third of the people with ankylosing spondylitis have severe disease, which reduces life expectancy. However, if your disease is under control, ankylosing spondylitis should not decrease your life expectancy.

Does the cold weather affect ankylosing spondylitis?

Although there is no definitive answer to this, avoiding extreme weather is generally better for people with ankylosing spondylitis. Many patients report that cold weather triggers pain in their joints.

Can I get a disability for ankylosing spondylitis?

If you have a severe case of the disease, then you might suffer from a disability. The long-standing inflammation and subsequent joint deformity might eventually lead to mobility restrictions.


Although ankylosing spondylitis is an incurable disease, you can keep it in control by paying attention to all the factors discussed in this article.

An experienced rheumatologist can prescribe a custom treatment plan to help you maintain a long and happy life with ankylosing spondylitis.

To search for the best orthopedic doctors worldwide, please use the Mya Care search engine.

About the Author:
Dr. Mersad is a medical doctor, author, and editor based in Germany. He's managed to publish several research papers early in his career. He is passionate about spreading medical knowledge. Thus, he spends a big portion of his time writing educational articles for everyone to learn.



Disclaimer: Please note that Mya Care does not provide medical advice, diagnosis, or treatment. The information provided is not intended to replace the care or advice of a qualified health care professional. The views expressed are personal views of the author and do not necessarily reflect the opinion of Mya Care. Always consult your doctor for all diagnoses, treatments, and cures for any diseases or conditions, as well as before changing your health care regimen. Do not reproduce, copy, reformat, publish, distribute, upload, post, transmit, transfer in any manner or sell any of the materials in this blog without prior written permission from